DNA-binding protein Dps, conserved site <p> <taxon tax_id="562">Escherichia coli</taxon> protein Dps [<cite idref="PUB00001907"/>] is a DNA-binding protein, synthesized during prolonged starvation, that seems to protect DNA from oxidative damage. Dps binds DNA without any apparent sequence specificity. It is a protein of about 19 Kd that associates into a complex of 12 subunits forming two stacked hexameric rings.</p><p>Proteins similar to Dps have been found in other bacteria:</p> <ul> <li> <taxon tax_id="1423">Bacillus subtilis</taxon> protein MrgA.</li> <li>Antigen TpF1/TyF1 from <taxon tax_id="160">Treponema pallidum</taxon>.</li> <li> <taxon tax_id="730">Haemophilus ducreyi</taxon> fine tangled pili major subunit (gene ftpA).</li> <li> <taxon tax_id="210">Helicobacter pylori</taxon> neutrophil-activating protein A (gene napA).</li> <li> <taxon tax_id="1642">Listeria innocua</taxon> non-heme iron-containing ferritin.</li> <li> <taxon tax_id="1140">Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)</taxon> nutrient-stress induced DNA binding protein (gene dpsA).</li> <li>A low-temperature induced protein from <taxon tax_id="1172">Anabaena variabilis</taxon>.</li> <li> <taxon tax_id="727">Haemophilus influenzae</taxon> hypothetical protein HI1349.</li> <li> <taxon tax_id="1148">Synechocystis sp.</taxon> (strain PCC 6803) hypothetical protein Slr1894.</li> <li>A hypothetical protein encoded in the 5' region of a gene coding for a bromoperoxidase, in plasmid pOP2621 of <taxon tax_id="1894">Streptomyces aureofaciens</taxon>.</li> </ul><p>All these proteins share a conserved region of about 50 residues in their central region. This entry corresponds to two conserved sites derived from both extremities of that region.</p>